MUTYH antibody (Center)

Catalog No. ABIN2854424

The Rabbit Polyclonal anti-MUTYH antibody has been validated for WB. It is suitable to detect MUTYH in samples from Human and Mouse.

Quick Overview for MUTYH antibody (Center) (ABIN2854424)

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUTYH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MUTYH Antibody

Binding Specificity: Center

Characteristics: Rabbit polyclonal antibody to MYH (mutY homolog (E. coli))
MUTYH antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human MUTYH. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Comment:

Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , NIH-3T3

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.39 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for MUTYH

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Alternative Name: MUTYH

Background: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Nucleus

Molecular Weight: 60 kDa

Gene ID: 4595

Pathways: DNA Damage Repair