AXIN2 antibody
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- Target See all AXIN2 Antibodies
- AXIN2 (Axin 2 (AXIN2))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AXIN2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
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Rabbit polyclonal antibody to axin 2 (axin 2 (conductin, axil))
axin 2 antibody [N2C2], Internal - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human Axin 2. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product AXIN2 Primary Antibody
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- Application Notes
- IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- AXIN2 (Axin 2 (AXIN2))
- Alternative Name
- axin 2 (AXIN2 Products)
- Synonyms
- AXIL antibody, ODCRCS antibody, axil antibody, wu:fb37c08 antibody, zgc:111942 antibody, axin-2 antibody, xarp antibody, MGC81576 antibody, arp-A antibody, axin2 antibody, Axi1 antibody, Axil antibody, Conductin antibody, axin 2 antibody, axin 2 (conductin, axil) antibody, axin 2 (conductin, axil) S homeolog antibody, AXIN2 antibody, axin2 antibody, axin2.S antibody, Axin2 antibody
- Background
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The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Cellular Localization: Cytoplasm - Molecular Weight
- 94 kDa
- Gene ID
- 8313
- UniProt
- Q9Y2T1
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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