DEDD antibody

Catalog No. ABIN2856831

Product Details anti-DEDD Antibody

Target: DEDD (Death Effector Domain Containing (DEDD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEDD antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to DEDD (death effector domain containing)
DEDD antibody [N3C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human DEDD. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: mouse leukocyte treated with CFA

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.42 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for DEDD

Target: DEDD (Death Effector Domain Containing (DEDD))

Alternative Name: death effector domain containing (DEDD Products)

Synonyms: CASP8IP1 antibody, DEDD1 antibody, DEFT antibody, FLDED1 antibody, Dedpro1 antibody, KE05 antibody, Deft antibody, death effector domain containing antibody, death effector domain-containing antibody, DEDD antibody, Dedd antibody

Background: This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.

Cellular Localization: Cytoplasm , Nucleus , nucleolus

Molecular Weight: 37 kDa

Gene ID: 9191

UniProt: O75618