Neuroketals antibody
Reactivity: Mammalian
IHC, ELISA, WB
Host: Goat
Polyclonal
unconjugated
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- Target
- Neuroketals
- Reactivity
- Mammalian
- Host
- Goat
- Clonality
- Polyclonal
- Application
- Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
- Immunogen
- Neuroketal antibody was raised in goat using neuroketal-Conjugate as the immunogen.
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- Application Notes
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ELISA: >1:4,000, IHC-P: >1:200, WB: >1:2,000
Optimal conditions should be determined by the investigator. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Neat serum, with 0.1 % NaN3 as a preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
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- Target
- Neuroketals
- Alternative Name
- Neuroketal
- Background
- Neuroketals and neuroprostanes are a class of compounds that result from the oxidation of docosahexenoic acid (DHA), which is enriched in the brain and retina, especially the synaptic membranes and retina. DHA is a membrane polyunsaturated fatty acid that is especially vulnerable to free radical attack because hydrogen radicals easily remove its double bonds. The DHA is oxidized to isoprostane-like compounds called neuroprostanes, which can dehydrate to form highly reactive A4/J4 neuroprostanes . Neuroprostanes can also undergo rearrangement to form D- and E-ring neuroprostanes. These reactive neuroprostanes are called neuroketals because DHA is so concentrated in the nervous system.
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