Adiponectin Receptor 1 antibody

Catalog No. ABIN290045

Product Details anti-Adiponectin Receptor 1 Antibody

Target: Adiponectin Receptor 1 (ADIPOR1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adiponectin Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody was prepared from the serum of a rabbit immunized with a partial peptide representing the N-terminal domain of Human AdipoR1, and purified bypeptide affinity chromatography.

Immunogen: Partial peptide of Human AdipoR1

Application Details

Application Notes: Working dilution For Western blotting: 1.0ug/ml

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for Adiponectin Receptor 1

Target: Adiponectin Receptor 1 (ADIPOR1)

Alternative Name: AdipoR1 (ADIPOR1 Products)

Synonyms: ADIPOR1 antibody, adipor1 antibody, zgc:92893 antibody, ACDCR1 antibody, CGI45 antibody, PAQR1 antibody, TESBP1A antibody, 2810031L11Rik antibody, CGI-45 antibody, Paqr1 antibody, zgc:55386 antibody, wu:fj02d08 antibody, acdcr1 antibody, cgi-45 antibody, cgi45 antibody, paqr1 antibody, tesbp1a antibody, MGC53458 antibody, Adipor1 antibody, adiponectin receptor 1 antibody, adiponectin receptor 1a antibody, adiponectin receptor 1b antibody, adiponectin receptor 1 S homeolog antibody, adiponectin receptor 1 L homeolog antibody, ADIPOR1 antibody, adipor1a antibody, Adipor1 antibody, adipor1b antibody, adipor1 antibody, adipor1.S antibody, adipor1.L antibody

Background: Obesity is a common etiology of diabetes mellitus and other diseases. Certain adipocytokines areconsidered beneficial due to their ability to enhance insulin sensitivity, while others, considereddetrimental, enhance insulin resistance.The beneficial adipocytokine adiponectin displays both anti-diabetic and anti-arteriosclerotic effects. Two distinct adiponectin receptors have been identified. Both AdipoR1 and AdipoR2 are seven-passtransmembrane receptors but are structurally, topologically, and functionally distinct from G-proteincoupled receptors (GPCR) (Ref.1). AdipoR1 is most abundant in muscle whereas AdipoR2 is mostabundant in liver. Both receptors promote fatty acid oxidation and glucose uptake by AMP-activatedprotein kinase and PPAR gamma.PPAR agonists are reported to increase expression of activated adiponectin. PPAR gamma agonists also increase expression of adiponectin receptors (Ref.2). Such findings have focused attention on the role of AdipoR1 in PPAR agonist development.

Pathways: AMPK Signaling