ADRB3 antibody

Catalog No. ABIN290046

Product Details anti-ADRB3 Antibody

Target: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRB3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody was prepared from the serum of a rabbit immunized with a partial peptide representing the C-terminal domain of Human beta3-AR, and purified by peptide affinity chromatography.

Immunogen: Partial peptide of Human beta3-AR

Application Details

Application Notes: Working dilution For Western blotting: 5.0ug/ml

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for ADRB3

Target: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Alternative Name: beta3-AR (ADRB3 Products)

Synonyms: BETA3AR antibody, Adrb-3 antibody, ADRB antibody, BAR3 antibody, B3AR antibody, GPCR antibody, im:7154935 antibody, si:ch211-215f19.1 antibody, zgc:194843 antibody, zgc:194852 antibody, adrenoceptor beta 3 antibody, adrenergic receptor, beta 3 antibody, adrenoceptor beta 3a antibody, adrenoceptor beta 3b antibody, ADRB3 antibody, Adrb3 antibody, adrb3a antibody, adrb3b antibody

Background: The neurotransmitter/hormone adrenaline (epinephrine, adrenalin) plays a central role in the mammalianstress response, increasing heart rate, raising blood pressure, and increasing blood glucose levels upon enteringthe blood stream.Adrenaline is secreted primarily by the adrenal medulla. Adrenaline activates both alpha-adrenergic receptors and beta-adrenergic receptors. Three subtypes of beta adrenergic receptors are known, beta1, beta2, beta3, expressed primarily inheart, respiratory tissue, and adipose tissue, respectively. Beta3-receptors are particularly abundant in brown adipocytes and play important roles in lipolysis andtheremoregulation. (Ref.1, Ref.2) Recently this receptor has received attention from researchers intereseted in type 2diabetes mellitus and obesity. It is also being considered as a therapertic target for heart failure (Ref.3).

Pathways: cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Brown Fat Cell Differentiation