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BAX antibody (AA 1-100)

This Rabbit Polyclonal antibody specifically detects BAX in WB, IHC, IF and IP. It exhibits reactivity toward Human and has been mentioned in 13+ publications.
Catalog No. ABIN3020683

Quick Overview for BAX antibody (AA 1-100) (ABIN3020683)

Target

See all BAX Antibodies
BAX (BCL2-Associated X Protein (BAX))

Reactivity

  • 236
  • 153
  • 136
  • 46
  • 32
  • 24
  • 24
  • 18
  • 16
  • 10
  • 9
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 158
  • 94
  • 3
  • 1
Rabbit

Clonality

  • 168
  • 88
Polyclonal

Conjugate

  • 135
  • 13
  • 11
  • 9
  • 7
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This BAX antibody is un-conjugated

Application

  • 222
  • 94
  • 77
  • 67
  • 52
  • 52
  • 46
  • 44
  • 35
  • 22
  • 11
  • 8
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
  • Binding Specificity

    • 32
    • 25
    • 18
    • 16
    • 15
    • 12
    • 10
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
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    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100

    Sequence

    MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF

    Cross-Reactivity

    Human, Mouse, Rat

    Characteristics

    Polyclonal Antibodies

    Purification

    Affinity purification

    Immunogen

    A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bax (NP_620116.1).

    Isotype

    IgG
  • Application Notes

    WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200,IP,1:50 - 1:200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid freeze / thaw cycles

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Zhao, Liu, Lin, Huang, He, Zhang, Dong, Wen, Rao, Liao, Shi: "The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1." in: Molecular cancer, Vol. 17, Issue 1, pp. 69, (2019) (PubMed).

    Bei, Xu, Lv, Yu, Xu, Che, Das, Tigges, Toxavidis, Ghiran, Shah, Li, Zhang, Das, Xiao: "Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury." in: Basic research in cardiology, Vol. 112, Issue 4, pp. 38, (2018) (PubMed).

    Guo, Wang, Mou, Zhao, Yang, Zhu, Pei, Zhu, Wang, Xu, Zeng, Yao: "Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity." in: Scientific reports, Vol. 8, Issue 1, pp. 7333, (2018) (PubMed).

    Li, Zhou, Yang, Li, Zhang, Wang, Jiao: "SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells." in: Biochemical and biophysical research communications, Vol. 496, Issue 4, pp. 1291-1295, (2018) (PubMed).

    Gu, Liu, Li, Xie, Yao, Zhu, Xu, Dai, Zhong, Zhu, Ding, Zhou: "Serum-Derived Extracellular Vesicles Protect Against Acute Myocardial Infarction by Regulating miR-21/PDCD4 Signaling Pathway." in: Frontiers in physiology, Vol. 9, pp. 348, (2018) (PubMed).

    Li, Liu, Xie, Gu, Dai, Yao, Zhou: "Serum Exosomes Attenuate H2O2-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2." in: Journal of cardiovascular translational research, (2018) (PubMed).

    Ding, Wen: "Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis." in: Journal of natural medicines, Vol. 72, Issue 4, pp. 857-866, (2018) (PubMed).

    Chen, Cheng, Gao, Zhan, Wang, Qu, Li, Wang, Chen, Meng, Liu, Chen, Chen: "Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 7343090, (2018) (PubMed).

    Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

    Ge, Zhao, Wang, Li, Yu, He, Xue, Zhu, Zhang, Cheng, Jiang, Hu: "iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding." in: Cancer cell, Vol. 32, Issue 5, pp. 561-573.e6, (2017) (PubMed).

    Feng, Yu, Liu, Zhang, Cheng, Li, Tan, Luo, Jiang: "KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 80-91, (2014) (PubMed).

    He, Zhang, Wang, Zhong, Shao, Zhu, Shen: "AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment." in: American journal of translational research, Vol. 5, Issue 3, pp. 359-67, (2013) (PubMed).

    Bao, Lu, Bin, Chang, Meng, Zhou, Guo, Zhao: "Systematic screen with kinases inhibitors reveals kinases play distinct roles in growth of osteoprogenitor cells." in: International journal of clinical and experimental pathology, Vol. 6, Issue 10, pp. 2082-91, (2013) (PubMed).

  • Target

    BAX (BCL2-Associated X Protein (BAX))

    Alternative Name

    BAX

    Background

    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.,BCL2L4,BAX,Cancer,Invasion and Metastasis,Signal Transduction,PI3K-Akt Signaling Pathway,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Bcl 2 family,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Endocrine & Metabolism,Mitochondrial metabolism,Warburg Effect,Neuroscience,Neurodegenerative Diseases,BAX

    Molecular Weight

    4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa

    Gene ID

    581

    UniProt

    Q07812

    Pathways

    p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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