NCOA1 antibody (AA 1222-1441)

Catalog No. ABIN3021492

This Rabbit Polyclonal antibody specifically detects NCOA1 in WB. It exhibits reactivity toward Human.

Quick Overview for NCOA1 antibody (AA 1222-1441) (ABIN3021492)

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NCOA1 Antibody

Binding Specificity: AA 1222-1441

Sequence: NPQMQQNVFQ YPGAGMVPQG EANFAPSLSP GSSMVPMPIP PPQSSLLQQT PPASGYQSPD MKAWQQGAIG NNNVFSQAVQ NQPTPAQPGV YNNMSITVSM AGGNTNVQNM NPMMAQMQMS SLQMPGMNTV CPEQINDPAL RHTGLYCNQL SSTDLLKTEA DGTQQVQQVQ VFADVQCTVN LVGGDPYLNQ PGPLGTQKPT SGPQTPQAQQ KSLLQQLLTE

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1222-1441 of human NCOA1 (NP_003734.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NCOA1

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Alternative Name: NCOA1

Background: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.,NCOA1,F-SRC-1,KAT13A,RIP160,SRC1,bHLHe42,bHLHe74,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Acetylation,Nuclear Receptor Signaling,Nuclear hormone receptors,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,NCOA1

Molecular Weight: 152 kDa/156 kDa

Gene ID: 8648

UniProt: Q15788

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha