POLH antibody (AA 20-320)

Catalog No. ABIN3022621

The Rabbit Polyclonal anti-POLH antibody has been validated for WB and IF. It is suitable to detect POLH in samples from Human.

Quick Overview for POLH antibody (AA 20-320) (ABIN3022621)

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLH antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-POLH Antibody

Binding Specificity: AA 20-320

Sequence: QVEQRQNPHL RNKPCAVVQY KSWKGGGIIA VSYEARAFGV TRSMWADDAK KLCPDLLLAQ VRESRGKANL TKYREASVEV MEIMSRFAVI ERASIDEAYV DLTSAVQERL QKLQGQPISA DLLPSTYIEG LPQGPTTAEE TVQKEGMRKQ GLFQWLDSLQ IDNLTSPDLQ LTVGAVIVEE MRAAIERETG FQCSAGISHN KVLAKLACGL NKPNRQTLVS HGSVPQLFSQ MPIRKIRSLG GKLGASVIEI LGIEYMGELT QFTESQLQSH FGEKNGSWLY AMCRGIEHDP VKPRQLPKTI G

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human DNA polymerase eta (NP_006493.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for POLH

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Alternative Name: POLH

Background: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.,POLH,RAD30,RAD30A,XP-V,XPV,Epigenetics & Nuclear Signaling,POLH

Molecular Weight: 46 kDa/78 kDa

Gene ID: 5429

UniProt: Q9Y253

Pathways: DNA Damage Repair