STRADB antibody (Internal Region)

Catalog No. ABIN3024145

Product Details anti-STRADB Antibody

Target: STRADB (STE20-Related Kinase Adaptor beta (STRADB))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRADB antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A affinity chromatography

Immunogen: A recombinant protein fragment from the interior region of human Als2Cr2 was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: Provided assay concentrations are suggestions only, Als2Cr2 antibody titration may be required for optimal results. This antibody will detect the 418 (ILPIP alpha) and 280 (ILPIP beta) amino acid isoforms.\. Western blot: 5-10 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Als2Cr2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for STRADB

Target: STRADB (STE20-Related Kinase Adaptor beta (STRADB))

Alternative Name: Als2Cr2 (STRADB Products)

Synonyms: Als2cr2 antibody, RGD1559449 antibody, als2cr2 antibody, MGC82468 antibody, STRADB antibody, ALS2CR2 antibody, AA792893 antibody, B830008M19 antibody, D1Ucla2 antibody, ILPIP antibody, ILPIPA antibody, PRO1038 antibody, Papk antibody, Syradb antibody, CALS-21 antibody, PAPK antibody, STE20-related kinase adaptor beta antibody, STE20-related kinase adaptor beta L homeolog antibody, Stradb antibody, STRADB antibody, stradb.L antibody

Background: Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases. Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis.

Gene ID: 55437

Pathways: AMPK Signaling