CD46 antibody

Catalog No. ABIN3025892

This Mouse Monoclonal antibody specifically detects CD46 in FACS and IF. It exhibits reactivity toward Human and Baboon.

Quick Overview for CD46 antibody (ABIN3025892)

Target: CD46

Reactivity: Human, Baboon

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 169-1-E4-3

Product Details anti-CD46 Antibody

No Cross-Reactivity: Horse (Equine)

Purification: Protein G affinity chromatography

Immunogen: Stimulated human leukocytes were used as the immunogen for the CD46 antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal dilution of the CD46 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CD46 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for CD46

Target: CD46

Alternative Name: CD46

Background: Recognizes a protein of 52  kDa-58  kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Pathways: Regulation of Actin Filament Polymerization