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Ku70 + Ku80 antibody

KU80 Reactivity: Human, Primate FACS, IF, ICC Host: Mouse Monoclonal KU729 unconjugated
Catalog No. ABIN3026515
  • Target See all Ku70 + Ku80 (KU80) products
    Ku70 + Ku80 (KU80) (CG18801 Gene Product From Transcript CG18801-RA (KU80))
    Reactivity
    Human, Primate
    Host
    • 2
    • 1
    Mouse
    Clonality
    • 2
    • 1
    Monoclonal
    Conjugate
    • 2
    • 1
    This Ku70 + Ku80 antibody is un-conjugated
    Application
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)
    No Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Chicken
    Characteristics
    This antibody recognizes a dimer of two proteins of 70 kDa (Ku70) and ~80 kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting. The Ku70 + Ku80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
    Purification
    Protein G purified monoclonal antibody
    Immunogen
    Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.
    Clone
    KU729
    Isotype
    IgG1 kappa
  • Application Notes
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Ku70 + Ku80 antibody to be titered up or down for optimal performance.\. Flow cytometry: 0.5-1 μg/10e6 cells,IF: 0.5-1.0 μg/mL,Immunocytochemistry (Acetone-fixed cells): 0.25-0.5 μg/mL for 30 minutes at RT
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Preservative
    Azide free
    Storage
    4 °C,-20 °C
    Storage Comment
    Store the Ku70 + Ku80 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    Ku70 + Ku80 (KU80) (CG18801 Gene Product From Transcript CG18801-RA (KU80))
    Alternative Name
    Ku70 + Ku80 (KU80 Products)
    Background
    This antibody recognizes a dimer of two proteins of 70  kDa (Ku70) and ~80  kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting. The Ku70 + Ku80 dimer is important for function of a 460  kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
    Gene ID
    2547
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