Ku70 + Ku80 antibody (CF®488A)

Catalog No. ABIN7880388

The Mouse Monoclonal anti-Ku70 + Ku80 antibody is suitable to detect Ku70 + Ku80 in samples from Human. It has been validated for IF and FACS.

Quick Overview for Ku70 + Ku80 antibody (CF®488A) (ABIN7880388)

Target: Ku70 + Ku80 (KU80) (CG18801 Gene Product From Transcript CG18801-RA (KU80))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ku70 + Ku80 antibody is conjugated to CF®488A

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: KU729

Product Details anti-Ku70 + Ku80 Antibody (CF®488A)

Purpose: Ku70 + Ku80 Antibody

Purification: Protein G affinity chromatography

Immunogen: Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Ku70 + Ku80 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the Ku70 + Ku80 antibody at 2-8oC, protected from light.

Target Details for Ku70 + Ku80

Target: Ku70 + Ku80 (KU80) (CG18801 Gene Product From Transcript CG18801-RA (KU80))

Alternative Name: Ku70 + Ku80

Background: Recognizes a dimer of two proteins of 70 kDa and ~80 kDa, identified as two subunits of Ku. MAb KU729 recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.