IFNA antibody

Catalog No. ABIN3026804

This Mouse Monoclonal antibody specifically detects IFNA in ELISA. It exhibits reactivity toward Human.

Quick Overview for IFNA antibody (ABIN3026804)

Target: IFNA (Interferon alpha (IFNA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA antibody is un-conjugated

Application: ELISA

Clone: 2-52

Product Details anti-IFNA Antibody

Characteristics: This mAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

Purification: Protein G affinity chromatography

Immunogen: Purified recombinant human IFNA1 was used as the immunogen for the Interferon alpha antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal dilution of the Interferon alpha antibody should be determined by the researcher.\. ELISA: order BSA/azide-free format for coating

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Interferon alpha antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for IFNA

Target: IFNA (Interferon alpha (IFNA))

Alternative Name: Interferon alpha

Background: This mAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

Pathways: JAK-STAT Signaling, TLR Signaling, Hepatitis C, Inflammasome