MYBL2 antibody (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2) (N-Term)

Details for Product anti-MYBL2 Antibody No. ABIN3029533
Target
Binding Specificity
N-Term
19
15
10
8
8
5
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse, Rat
93
75
66
5
4
4
4
4
3
3
2
1
Host
Rabbit
85
8
7
Clonality
Polyclonal
Conjugate
This MYBL2 antibody is un-conjugated
7
5
5
4
4
4
4
4
4
3
3
3
3
3
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
37
32
15
14
11
5
4
2
2
2
1
Options
Immunogen An amino acid sequence from the N-terminus of human MYBL2/B-MYB (MSRRTRCEDLDELHYQD) was used as the immunogen for this MYBL2 antibody (100% mouse homology).
Isotype IgG
Purification Antigen affinity
Target
Alternative Name MYBL2 (MYBL2 Antibody Abstract)
Background V-MYB avian myeloblastosis viral oncogene homolog-like 2, also called MYB-related gene B-MYB, is a protein that in humans is encoded by the MYBL2 gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. Barletta et al.(1991) assigned the gene to chromosome Xq13. However, Noben-Trauth et al.(1996) demonstrated that this assignment was an error. Using mouse Mybl2 cDNA clones as probes, they assigned the gene in an interspecific backcross panel to distal mouse chromosome 2. Using human cDNA probes in combination with fluorescence in situ hybridization analysis, they localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders and shows high homology of Synteny to mouse chromosome 2. It has been shown to activate the cell division cycle 2, Cyclin D1, and Insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
UniProt P10244
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases, Chromatin Binding
Application Notes The stated application concentrations are suggested starting amounts. Titration of the MYBL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Storage -20 °C
Storage Comment After reconstitution, the MYBL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Images
Image no. 1 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) IHC-P: MYBL2 antibody testing of human tonsil tissue
Image no. 2 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) IHC-P: MYBL2 antibody testing of rat brain tissue
Image no. 3 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) Western blot testing with MYBL2 antibody and recombinant protein, 47KD with tag; Lan...
Image no. 4 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) Western blot testing with MYBL2 antibody; Lane 1: rat spleen; 2: (r) thymus; 3: (r...
Image no. 5 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) ICC testing of MYBL2 antibody and A549 cells
Image no. 6 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) Western blot testing with MYBL2 antibody
Image no. 7 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) IHC-P: MYBL2 antibody testing of rat brain tissue. HIER: steamed with pH6 citrate buf...
Image no. 8 for anti-V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) (N-Term) antibody (ABIN3029533) IHC-P: MYBL2 antibody testing of human tonsil tissue. HIER: steamed with pH6 citrate ...