TFF1 antibody (AA 67-84)

Catalog No. ABIN3029755

Product Details anti-TFF1 Antibody

Target: TFF1 (Trefoil Factor 1 (TFF1))

Binding Specificity: AA 67-84

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids 67-84 (WCFYPNTIDVPPEEECEF-human) were used as the immunogen for this pS2 antibody.

Isotype: IgG

Application Details

Application Notes: Titration of the pS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: The lyophilized pS2 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Alternative Name: pS2 (Estrogen Inducible Protein) (TFF1 Products)

Synonyms: BCEI antibody, D21S21 antibody, HP1.A antibody, HPS2 antibody, pNR-2 antibody, pS2 antibody, Bcei antibody, PS2 antibody, bcei antibody, d21s21 antibody, hp1.a antibody, hps2 antibody, p1 antibody, p1-a antibody, pnr-2 antibody, ps2 antibody, tff1 antibody, xP1 antibody, xp1-L antibody, xp1 antibody, TFF1 antibody, Ps2 antibody, trefoil factor 1 antibody, trefoil factor 1 S homeolog antibody, trefoil factor 1, gene 2 S homeolog antibody, TFF1 antibody, Tff1 antibody, tff1.S antibody, tff1.2.S antibody, LOC100358238 antibody

Background: Trefoil factor 1, also known as TFF1 and Estrogen inducible factor pS2, is a protein that in humans is encoded by the TFF1 gene. Family members are stable secretory proteins expressed in gastrointestinal mucosa that protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. The protein in normal human urine inhibited the growth of calcium oxalate crystals, and lack of pS2 may contribute to the development of idiopathic calcium oxalate kidney stones. Urinary pS2 showed an inhibitory potency similar to that of nephrocalcin, and inhibition was dose dependent and inhibited by pS2 antisera, particularly by antisera directed to the pS2 C terminus.

UniProt: P04155

Pathways: EGFR Signaling Pathway