Caspase 1 antibody (N-Term, Subunit p20)

Catalog No. ABIN3030287

Product Details anti-Caspase 1 Antibody

Target: Caspase 1 (CASP1)

Binding Specificity: N-Term, Subunit p20

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of mouse CASP1 (LEKAQKLWKENPSEIYPIMNT) was used as the immunogen for this Caspase-1 antibody. This sequence is from the p20 subunit.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Caspase-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Caspase-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Caspase 1

Target: Caspase 1 (CASP1)

Alternative Name: Caspase-1 (CASP1 Products)

Synonyms: ICE antibody, IL1BC antibody, P45 antibody, Il1bc antibody, Ice antibody, CASP1 antibody, CG5370 antibody, DCP-1 antibody, DCP1 antibody, Dcp1 antibody, Dmel\\CG5370 antibody, ccp1 antibody, dcp-1 antibody, dcp1 antibody, l(2)01862 antibody, l(2)02132 antibody, caspase 1 antibody, caspase 1, apoptosis-related cysteine peptidase antibody, caspase 4, apoptosis-related cysteine peptidase antibody, Death caspase-1 antibody, caspase-1 antibody, caspase antibody, caspase recruitment domain-containing protein 16 antibody, caspase 4 antibody, CASP1 antibody, Casp1 antibody, CASP4 antibody, Dcp-1 antibody, Caspase1 antibody, LOC5564196 antibody, LOC451519 antibody

Background: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL-18, and IL-33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

UniProt: P29452

Pathways: Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome