Cullin 3 antibody
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- Target See all Cullin 3 (CUL3) Antibodies
- Cullin 3 (CUL3)
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cullin 3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
- Specificity
- This antibody reacts to amino acids 1-12 of Cul3 (N-terminus) coupled to KLH.
- Purification
- Delipidation and defibrination
- Immunogen
- Synthetic peptide
- Top Product
- Discover our top product CUL3 Primary Antibody
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- Application Notes
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Immunoprecipitation. Immunohistochemistry on paraffin sections: 1: 500. Western Blot: 1: 500 - 1: 1000. ELISA: 1: 2000 - 1: 10000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
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- Target
- Cullin 3 (CUL3)
- Alternative Name
- Cullin-3 (CUL3 Products)
- Synonyms
- CUL-3 antibody, Cullin-3 antibody, CUL-3-A antibody, Cullin-3-A antibody, cul3 antibody, cul3a antibody, CUL-3-B antibody, Cullin-3-B antibody, cul3b antibody, wu:fc37e01 antibody, CUL3 antibody, ATCUL3 antibody, ATCUL3A antibody, CUL3A antibody, T24P13.25 antibody, cullin 3 antibody, cullin 3A antibody, PHA2E antibody, AI467304 antibody, AW146203 antibody, mKIAA0617 antibody, cullin 3 antibody, cullin 3 L homeolog antibody, cullin 3 S homeolog antibody, cullin-3 antibody, Cullin-3 (CUL-3) antibody, cullin 3a antibody, CULlin antibody, CUL3 antibody, cul3 antibody, cul3.L antibody, cul3.S antibody, PTRG_11586 antibody, Smp_117580 antibody, cul3a antibody, Cul3 antibody, cul-3 antibody
- Background
- Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.Synonyms: CUL-3, CUL3, KIAA0617
- Gene ID
- 8452
- NCBI Accession
- NP_003581
- UniProt
- Q13618
- Pathways
- M Phase
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