GRIA2 antibody (AA 25-360)

Catalog No. ABIN3031067

The Rabbit Polyclonal anti-GRIA2 antibody has been validated for WB and IHC (p). It is suitable to detect GRIA2 in samples from Human, Rat and Mouse. There is 1 publication available.

Quick Overview for GRIA2 antibody (AA 25-360) (ABIN3031067)

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GRIA2 Antibody

Binding Specificity: AA 25-360

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 25-360) was used as the immunogen for this GLUR2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the GLUR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the GLUR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

References for anti-GRIA2 antibody (ABIN3031067)

Liu, Woo, Bukhari, Wang, Yan, Buosi, Ermekbaeva, Sista, Kotsiviras, LePochat, Chacko, Zhao, Kang: "Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10." in: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 95, (2022) (PubMed).

Target Details for GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Alternative Name: GLUR2

Background: Glutamate receptor 2, also known as GLUR2, is a protein that in humans is encoded by the GRIA2 gene. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse. Overexpression increases dendritic spine size and density in hippocampal neurons, and more remarkably, induces spine formation in GABA-releasing interneurons that normally lack spines.

Gene ID: 14800

Pathways: PI3K-Akt Signaling