ITPR3 antibody (AA 2411-2758)

Catalog No. ABIN3031328

The Rabbit Polyclonal anti-ITPR3 antibody has been validated for WB and IHC (p). It is suitable to detect ITPR3 in samples from Human, Mouse and Rat.

Quick Overview for ITPR3 antibody (AA 2411-2758) (ABIN3031328)

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ITPR3 Antibody

Binding Specificity: AA 2411-2758

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 2411-2758) was used as the immunogen for this IP3R antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the IP3R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the IP3R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ITPR3

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Alternative Name: IP3R

Background: Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. IP3R is an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in the gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.

Gene ID: 3708

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling