Tec Protein Tyrosine Kinase (TEC) (AA 612-631) antibody

Catalog No. ABIN3032066

The Rabbit Polyclonal anti-Tec Protein Tyrosine Kinase antibody is suitable to detect Tec Protein Tyrosine Kinase in samples from Human and Rat. It has been validated for WB and IHC (p).

Quick Overview for Tec Protein Tyrosine Kinase (TEC) (AA 612-631) antibody (ABIN3032066)

Target: Tec Protein Tyrosine Kinase (TEC)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 612-631

Purification: Antigen affinity

Immunogen: Amino acids 612-631 (FEDLLRTIDELVECEETFGR-human) were used as the immunogen for this Tec antibody (100% rat homology).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Tec antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Tec antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details

Target: Tec Protein Tyrosine Kinase (TEC)

Alternative Name: Tec

Background: TEC Protein Tyrosine Kinase, is an enzyme that in humans is encoded by the TEC gene. The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. By fluorescence in situ hybridization, Sato et al.(1994) mapped the gene to 4p12, the same location reported for TXK. Mouse Tec is a non-receptor type protein-tyrosine kinase that is highly expressed in many hematopoietic cell lines. Hantschel et al.(2007) identified TEC kinase and BTK kinase as major binders of the tyrosine kinase inhibitor dasatinib, which is used for treatment of BCR/ABL-positive CML.

UniProt: P42680

Pathways: Fc-epsilon Receptor Signaling Pathway