SSTR2 antibody (Middle Region)

Catalog No. ABIN3032694

Product Details anti-SSTR2 Antibody

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human Somatostatin Receptor 2 (RSNQWGRSSCTINWP) was used as the immunogen for this SSTR2 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the SSTR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SSTR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Alternative Name: SSTR2 Somatostatin Receptor 2 (SSTR2 Products)

Synonyms: Smstr2 antibody, SSTR-2 antibody, Smstr-2 antibody, sst2 antibody, SS2R antibody, SSTR2 antibody, MGC80373 antibody, somatostatin receptor 2 antibody, somatostatin receptor 2 L homeolog antibody, SSTR2 antibody, Sstr2 antibody, sstr2.L antibody

Background: Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin. mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.

UniProt: P30874