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TNFRSF10A antibody (N-Term)

TNFRSF10A Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN303303
  • Target See all TNFRSF10A Antibodies
    TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
    Binding Specificity
    • 13
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-20, N-Term
    Reactivity
    • 86
    • 5
    • 3
    • 1
    • 1
    Human
    Host
    • 46
    • 40
    Rabbit
    Clonality
    • 48
    • 38
    Polyclonal
    Conjugate
    • 47
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNFRSF10A antibody is un-conjugated
    Application
    • 43
    • 31
    • 25
    • 19
    • 17
    • 11
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody is specific to TNFRSF10A (CD261/TRAILR1).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    DEAE-Column Chromatography
    Immunogen
    Synthetic Peptide corresponding to amino acid 1 to 20 of Human DR4 mature protein.
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    Discover our top product TNFRSF10A Primary Antibody
  • Application Notes
    Western Blot (1/500-1/1000). Immunohistochemistry on Paraffin Sections (5 μg/mL).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
  • Target
    TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
    Alternative Name
    CD261 / TRAILR1 (TNFRSF10A Products)
    Synonyms
    APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNFRSF10A antibody, TNF receptor superfamily member 10a antibody, tumor necrosis factor receptor superfamily member 26 antibody, tumor necrosis factor receptor superfamily, member 10a antibody, TNFRSF10A antibody, LOC510798 antibody
    Background
    Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A
    Gene ID
    8797
    NCBI Accession
    NP_003835
    UniProt
    O00220
    Pathways
    Apoptosis, Positive Regulation of Endopeptidase Activity
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