Lamin A/C antibody

Catalog No. ABIN8071366

This Mouse Monoclonal antibody specifically detects Lamin A/C in WB, IHC, IF and IP. It exhibits reactivity toward Human and Mouse.It has been mentioned in 1 publication

Quick Overview for Lamin A/C antibody (ABIN8071366)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: JOL4

Product Details anti-Lamin A/C Antibody

Purpose: Lamin A Monoclonal Antibody [JOL4] - Unpurified

Specificity: The antibody reacts with both recombinant and native lamin A in humans, binding to an epitope between amino acids 572-646

Purification: Unpurified

Immunogen: Recombinant human lamin A

Isotype: IgG

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try, IP: Use neat.  WB: 1/50. Predicted molecular weight: 74 kDa. 

Comment:

Myeloma/fusion partners:Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2-0/Ag4 myeloma cell line

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Tissue culture supernatant containing 02M Tris/HCl pH 74 and 510

Storage: 4 °C

References for anti-Lamin A/C antibody (ABIN8071366)

Vaughan, Alvarez-Reyes, Bridger, Broers, Ramaekers, Wehnert, Morris, Whitfield WGF, Hutchison: "Both emerin and lamin C depend on lamin A for localization at the nuclear envelope." in: Journal of cell science, Vol. 114, Issue Pt 14, pp. 2577-90, (2001) (PubMed).

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A

Background: 70 kDa lamin antibody,CDCD1 antibody,CDDC antibody,CMD1A antibody,CMT2B1 antibody,EMD2antibody,FPL antibody,FPLD antibody,HGPS antibody,IDC antibody,LAMIN A antibody,lamin A/Cantibody,LAMIN C antibody,Lamin-A/C antibody,LDP1 antibody,LFP antibody,LGMD1B antibody,LMN 1antibody,LMN A antibody,LMN C antibody,LMN1 antibody,LMNA antibody,LMNA_HUMAN antibody,LMNC antibody,NYREN 32 antigen antibody,PRO1 antibody,Renal carcinoma antigen NY-REN-32 antibody

OMIM: 150330

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus