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ICAM1 antibody (Intercellular Adhesion Molecule 1) (AA 214-532) Primary Antibody

ICAM1 Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal unconjugated
Pubmed (36)
Catalog No. ABIN3042516
$280.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target
    ICAM1
    Binding Specificity
    • 16
    • 16
    • 16
    • 12
    • 12
    • 10
    • 9
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 214-532
    Reactivity
    • 264
    • 99
    • 51
    • 12
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Host
    • 153
    • 150
    • 35
    • 6
    • 3
    • 2
    Rabbit
    Clonality
    • 203
    • 143
    Polyclonal
    Conjugate
    • 167
    • 32
    • 31
    • 25
    • 11
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ICAM1 antibody is un-conjugated
    Application
    • 206
    • 157
    • 94
    • 86
    • 71
    • 53
    • 47
    • 46
    • 37
    • 29
    • 28
    • 22
    • 14
    • 11
    • 10
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Intercellular adhesion molecule 1(ICAM1) detection. Tested with WB, IHC-P in Human.
    Brand
    Picoband™
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Intercellular adhesion molecule 1(ICAM1) detection. Tested with WB, IHC-P in Human.
    Gene Name: intercellular adhesion molecule 1
    Protein Name: Intercellular adhesion molecule 1
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human ICAM1 recombinant protein (Position: L214-P532). Human ICAM1 shares 52% and 48% amino acid (aa) sequence identity with mouse and rat ICAM1, respectively.
    Isotype
    IgG
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Ma, Pan, Ren, Guo, Guo, Wei, Zheng, Chen: "15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 137, 2018 (PubMed).

    Ma, Pan, Chen, Guo, Zhao, Zheng, Chen: "Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion." in: Bioscience reports, Vol. 37, Issue 2, 2017 (PubMed).

    Wang, Sun, Shen, Wu, Liu, Yang, Ji, Ji, Li: "Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB." in: Oxidative medicine and cellular longevity, Vol. 2015, pp. 970156, 2016 (PubMed).

    Pan, Wang, Pu, Yao, Wang: "Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 21, pp. 2134-40, 2016 (PubMed).

    Wang, Wang, Li, Wu, Liu, Yang, Ji, Ji, Li: "The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142571, 2016 (PubMed).

    Tian, Wang, Cao, Zhong, Tu, Xiao, He, Zhai: "Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits." in: Chinese journal of integrative medicine, Vol. 21, Issue 3, pp. 229-33, 2015 (PubMed).

    Cheng, Zhang, Song, Feng: "Intercellular adhesion molecule-1 expression in the hippocampal CA1 region of hyperlipidemic rats with chronic cerebral ischemia." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1312-7, 2015 (PubMed).

    Ning, Liu, Lv, Yang, Zhang, Yu, Wang, Zhu: "Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats." in: Lipids in health and disease, Vol. 14, pp. 31, 2015 (PubMed).

    Chen, Zhang, Chen, Liu, Wang, Zhou, Qiu, Zhang, Teng, Mao, Liu, Wei, Li: "Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis." in: Annals of dermatology, Vol. 27, Issue 2, pp. 121-7, 2015 (PubMed).

    Fan, Yao, Li, Hu, Shao, Tian: "Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb." in: International journal of clinical and experimental pathology, Vol. 8, Issue 4, pp. 3451-9, 2015 (PubMed).

    Huang, Huang, Xiao, Yang, Lin, Diao: "Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 68, Issue 4, pp. 455-61, 2014 (PubMed).

    Wang, Zhao, Fang, Li, Shen, Cao, Zhu: "Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response." in: Critical care, Vol. 17, Issue 2, pp. R44, 2014 (PubMed).

    Fan, Jing, Yao, Li, Hu, Shao, Shen, Pan, Luo, Tian: "The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-?B in a rat model." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 191624, 2014 (PubMed).

    Wang, Shen, Li, Wang, Zhang: "2,3,4',5-tetrahydroxystilbene-2-O-?-D-glucoside suppresses expression of adhesion molecules in aortic wall of dietary atherosclerotic rats and promonocytic U937 cells." in: Cell biochemistry and biophysics, Vol. 67, Issue 3, pp. 997-1004, 2013 (PubMed).

    Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, 2013 (PubMed).

    Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: "Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage." in: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2953-65, 2011 (PubMed).

    Cui, Tian, Bai: "Protective effects of propofol on endotoxemia-induced acute kidney injury in rats." in: Clinical and experimental pharmacology & physiology, Vol. 38, Issue 11, pp. 747-54, 2011 (PubMed).

    Zhu, Lv, Chen, Wang, Zhong: "Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 31, Issue 4, pp. 441-5, 2011 (PubMed).

    Ji, Gao, Cai, Lu, Hu, Wang, Cheng, Gu, Wan, Zhang, Cao: "Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model." in: Journal of ethnopharmacology, Vol. 134, Issue 3, pp. 624-9, 2011 (PubMed).

    Xu, Feng, Wang, Zhu, Zheng, Xiang, He, Tang: "Calycosin protects HUVECs from advanced glycation end products-induced macrophage infiltration." in: Journal of ethnopharmacology, Vol. 137, Issue 1, pp. 359-70, 2011 (PubMed).

  • Target
    ICAM1
    Alternative Name
    ICAM1 (ICAM1 Antibody Abstract)
    Synonyms
    BB2, CD54, P3.58, Icam-1, Ly-47, MALA-2, ICAM, ICAM-1, ICAM1, intercellular adhesion molecule 1, intercellular adhesion molecule-1, ICAM1, Icam1, ICAM-1
    Target Type
    Viral Protein
    Background
    Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin. The normal function of human ICAM-1 is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1). It is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.

    Synonyms: Antigen identified by monoclonal antibody BB2 antibody|BB 2 antibody|BB2 antibody|CD 54 antibody|CD_antigen=CD54 antibody|CD54 antibody|CD54 antigen antibody|Cell surface glycoprotein P3.58 antibody|Human rhinovirus receptor antibody|ICAM 1 antibody|ICAM-1 antibody|ICAM1 antibody|ICAM1_HUMAN antibody|intercellular adhesion molecule 1(CD54)|human rhinovirus receptor antibody|Intercellular adhesion molecule 1 antibody|Major group rhinovirus receptor antibody|MALA 2 antibody|MALA2 antibody|MyD 10 antibody|MyD10 antibody|P3.58 antibody|Surface antigen of activated B cells antibody|Surface antigen of activated B cells, BB2 antibody
    Gene ID
    3383
    UniProt
    P05362
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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