IL-13 antibody (AA 25-146)

Catalog No. ABIN3042736

Product Details anti-IL-13 Antibody

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Binding Specificity: AA 25-146

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-13 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Interleukin-13(IL13) detection. Tested with IHC-P in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Interleukin-13(IL13) detection. Tested with IHC-P in Human.
Gene Name: interleukin 13
Protein Name: Interleukin-13

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human IL-13 recombinant protein (Position: L25-N146). Human IL-13 shares 57% and 62% amino acid (aa) sequence identity with mouse and rat IL-13, respectively.

Isotype: IgG

Application Details

Application Notes: IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-IL-13 antibody (ABIN3042736)

Li, Li, Zuo, Ke, Yan, Wen, Zhang, Yang: "T-helper type-2 contact hypersensitivity of Balb/c mice aggravated by dibutyl phthalate via long-term dermal exposure." in: PLoS ONE, Vol. 9, Issue 2, pp. e87887, (2014) (PubMed).

Target Details for IL-13

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Alternative Name: IL13 (IL13 Products)

Synonyms: IL13 antibody, IL-13 antibody, P600 antibody, Il-13 antibody, L13 antibody, interleukin 13 antibody, IL13 antibody, Il13 antibody

Background: IL-13, Interleukin 13, is a protein that in humans is encoded by the IL-13 gene. IL-13 is a kind of cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, which is an important mediator of allergic inflammation and disease. The IL-13 gene is mapped to 5q23-q31. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. This gene acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function.

Synonyms: Allergic rhinitis antibody|ALRH antibody|BHR1 antibody|Bronchial hyperresponsiveness 1 (bronchial asthma) antibody|IL 13 antibody|IL-13 antibody|Il13 antibody|IL13_HUMAN antibody|Interleukin 13 antibody|Interleukin-13 antibody|MGC116786 antibody|MGC116788 antibody|MGC116789 antibody|NC30 antibody|P600 antibody

Gene ID: 3596

UniProt: P35225

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport