Integrin Alpha2b antibody (C-Term)

Catalog No. ABIN3043254

The Rabbit Polyclonal anti-Integrin Alpha2b antibody (ABIN3043254) specifically detects Integrin Alpha2b in WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Integrin Alpha2b antibody (C-Term) (ABIN3043254)

Target: Integrin Alpha2b (CD41)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Integrin Alpha2b Antibody

Binding Specificity: C-Term

Purpose: Anti-CD41/Integrin alpha 2b/ITGA2B Antibody

Sequence: EAELAVHLPQ GAHYMRALSN VEGFERLICN QKKEN

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by four amino acids.

Characteristics: Anti-CD41/Integrin alpha 2b/ITGA2B Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ITGA2B, different from the related mouse sequence by four amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: ITGA2B

Background:

Background: Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. It is mapped to 17q21.32. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene Full Name: integrin subunit alpha 2b

Sequence Similarities: Contains 1 HMG box DNA-binding domain.

Molecular Weight: 120-135 kDa

Gene ID: 3674

UniProt: P08514

Pathways: Integrin Complex