Neuregulin 1 antibody (AA 2-241)

Catalog No. ABIN3043580

Product Details anti-Neuregulin 1 Antibody

Target: Neuregulin 1 (NRG1)

Binding Specificity: AA 2-241

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Pro-neuregulin-1, membrane-bound isoform(NRG1) detection. Tested with WB in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Pro-neuregulin-1, membrane-bound isoform(NRG1) detection. Tested with WB in Human.
Gene Name: neuregulin 1
Protein Name: Pro-neuregulin-1, membrane-bound isoform

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NRG1 recombinant protein (Position: S2-K241). Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-Neuregulin 1 antibody (ABIN3043580)

Wang, Zhou, Ding, Zhu, Jiang, Fu, Wang, Hu, Ge: "Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6596-606, (2015) (PubMed).

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1 (NRG1 Products)

Synonyms: 6030402G23Rik antibody, ARIA antibody, D230005F13Rik antibody, GGF antibody, GGFII antibody, HRG antibody, HRGalpha antibody, Hgl antibody, NDF antibody, SMDF antibody, GGF2 antibody, HGL antibody, HRG1 antibody, HRGA antibody, MST131 antibody, NRG-1 antibody, heregulin antibody, nrg1-A antibody, pro-neuregulin-1 antibody, NRG1 antibody, wu:fm70e01 antibody, DKFZp459A1838 antibody, neuregulin 1 antibody, histidine rich glycoprotein antibody, neuregulin 1 L homeolog antibody, Nrg1 antibody, NRG1 antibody, HRG antibody, nrg1.L antibody, nrg1 antibody

Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Synonyms: Acetylcholine receptor inducing activity antibody|Acetylcholine receptor-inducing activity antibody|Acetylcholine receptor-inducing activity, CHICK, homolog of antibody|ARIA antibody|Breast cancer cell differentiation factor p45 antibody|ERBB2 p185 activator antibody|GGF 2 antibody|GGF antibody|GGF2 antibody|Glial growth factor antibody|Heregulin alpha antibody|Heregulin antibody|heregulin, alpha (45kD, ERBB2 p185-activator) antibody|HGL antibody|HRG 1 antibody|HRG antibody|HRG1 antibody|HRGA antibody|MST131 antibody|NDF antibody|Neu differentiation factor antibody|Neuregulin 1 antibody|neuregulin 1 type IV beta 1a antibody|neuregulin 1 type IV beta 3 antibody|Neuregulin-1 antibody|Neuregulin1 antibody|NRG 1 antibody|nrg1 antibody|NRG1-IT2 antibody|NRG1_HUMAN antibody|OTTHUMP00000225398 antibody|OTTHUMP00000225419 antibody|OTTHUMP00000225420 antibody|OTTHUMP00000225421 antibody|OTTHUMP00000225422 antibody|OTTHUMP00000225477 antibody|OTTHUMP00000225545 antibody|OTTHUMP00000230603 antibody|OTTHUMP00000230605 antibody|Pro neuregulin 1 antibody|Pro NRG1 antibody|pro-neuregulin-1, membrane-bound isoform antibody|Pro-NRG1 antibody|Proneuregulin 1 antibody|ProNRG1 antibody|Sensory and motor neuron derived factor antibody|Sensory and motor neuron-derived factor antibody|SMDF antibody

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation