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C-MYC antibody (Myc Proto-Oncogene protein) (AA 257-439) Primary Antibody

MYC Reactivity: Human, Rat WB Host: Rabbit Polyclonal
Pubmed (13)
Catalog No. ABIN3043598
$280.00
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100 μg
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  • Target
    Binding Specificity
    AA 257-439
    Reactivity
    Human, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This C-MYC antibody is un-conjugated
    Application
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Myc proto-oncogene protein(MYC) detection. Tested with WB in Human,Rat.
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Myc proto-oncogene protein(MYC) detection. Tested with WB in Human,Rat.
    Gene Name: v-myc avian myelocytomatosis viral oncogene homolog
    Protein Name: Myc proto-oncogene protein
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human c-Myc recombinant protein (Position: E257-A439). Human c-Myc shares 91% amino acid (aa) sequences identity with both mouse and rat c-Myc.
    Isotype
    IgG
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for c-Myc is approximately 0.25 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Zhang, Chang, Zhao, Gao, Wang, Li, Zhang, Zhang, Xu: "The novel protein C9orf116 promotes rat liver cell line BRL-3A proliferation." in: PLoS ONE, Vol. 12, Issue 7, pp. e0180607, 2017 (PubMed).

    Zhang, Chang, Li, Zhang, Xu: "The novel protein C3orf43 accelerates hepatocyte proliferation." in: Cellular & molecular biology letters, Vol. 22, pp. 21, 2017 (PubMed).

    Hao, Wen, Li, Wang, Ni, Wang, Wang, Sun, Fan, Mao: "LiCl inhibits PRRSV infection by enhancing Wnt/?-catenin pathway and suppressing inflammatory responses." in: Antiviral research, Vol. 117, pp. 99-109, 2015 (PubMed).

    Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: "Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ..." in: European journal of medicinal chemistry, Vol. 86, pp. 165-74, 2014 (PubMed).

    Wang, Gu, Wan, Zhu, Qiu, Weng, Yu, He: "Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors." in: PLoS ONE, Vol. 8, Issue 2, pp. e52088, 2013 (PubMed).

    Li, Tian, Wang, Yao, Zhang, Lu, Sun, Gao, Xiao, Liu: "Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC." in: PLoS ONE, Vol. 8, Issue 10, pp. e77829, 2013 (PubMed).

    Yuan, Zhang, Cai, Ding, Wang, Chen, Wang, Yan, Lu: "Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer." in: Oncology reports, Vol. 29, Issue 6, pp. 2291-6, 2013 (PubMed).

    Zhang, Lu, Yang, Li, Sun, Tao, Liu, Zhang, Ma: "HILI inhibits TGF-? signaling by interacting with Hsp90 and promoting T?R degradation." in: PLoS ONE, Vol. 7, Issue 7, pp. e41973, 2012 (PubMed).

    Yang, Gu, Zheng, Li, Lian, Miao, Jiang, Wei: "RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11865-74, 2011 (PubMed).

    Qin, Hua, Shuang, Wang, Cui: "Effects of matrine on HepG2 cell proliferation and expression of tumor relevant proteins in vitro." in: Pharmaceutical biology, Vol. 48, Issue 3, pp. 275-81, 2010 (PubMed).

    Wang, Huo, Li, Fu, Xue, Yang, Wen, Ding, Duan: "Osteogenic role of endosomal chloride channels in MC3T3-E1 cells." in: Molecular and cellular biochemistry, Vol. 342, Issue 1-2, pp. 191-9, 2010 (PubMed).

    Liu, Liu, Bai, Li, Yang: "Molecular cloning, expression and subcellular distribution of an alternative splice variant of the porcine Sirt2 gene." in: Molecular biology reports, Vol. 37, Issue 3, pp. 1671-6, 2010 (PubMed).

    Long, Sun, Hu, Liang, Wang, Zhang, Cao, Zhen, Cui, Liu: "Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer." in: Oncology reports, Vol. 22, Issue 5, pp. 1189-95, 2009 (PubMed).

  • Target
    Alternative Name
    Myc Proto-Oncogene protein (MYC Antibody Abstract)
    Synonyms
    MRTL, MYCC, bHLHe39, c-Myc, CMYC, c-myc, C-MYC, LOC100136746, RNCMYC, mMyc, AU016757, Myc2, Niard, Nird, MYC, cmyc, zc-myc, c-myc II, myc-B, myc2, CMyc, CG10798, D-Myc, DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, anon-WO03040301.171, bHLHe57, c-MYC, d-myc, dMYC, dMyc, dMyc1, da, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc, MYC proto-oncogene, bHLH transcription factor, v-myc myelocytomatosis viral oncogene homolog, myelocytomatosis oncogene, MYC proto-oncogene, bHLH transcription factor a, MYC proto-oncogene, bHLH transcription factor L homeolog, v-myc myelocytomatosis viral oncogene homolog (avian), CG10798 gene product from transcript CG10798-RB, MYC, LOC100136746, Myc, myca, myc.L
    Background
    C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. C-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.

    Synonyms: AU016757 antibody|Avian myelocytomatosis viral oncogene homolog antibody|bHLHe39 antibody|c Myc antibody|c Myc Epitope Tag antibody|c Myc Tag antibody|Class E basic helix-loop-helix protein 39 antibody|MRTL antibody|Myc antibody|Myc Epitope Tag antibody|Myc protein antibody|Myc proto oncogene protein antibody|Myc proto-oncogene protein antibody|myc-related translation/localization regulatory factor antibody|MYC_HUMAN antibody|Myc2 antibody|MYCC antibody|Myelocytomatosis oncogene antibody|Niard antibody|Nird antibody|Oncogene Myc antibody|OTTHUMP00000158589 antibody|Proto-oncogene c-Myc antibody|Protooncogene homologous to myelocytomatosis virus antibody|RNCMYC antibody|Transcription factor p64 antibody|Transcriptional regulator Myc-A antibodyV-Myc avian myelocytomatosis viral oncogene homolog antibody|v-myc myelocytomatosis viral oncogene homolog (avian) antibody
    Gene ID
    4609
    UniProt
    P01106
    Pathways
    p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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