Presenilin 2 antibody (N-Term)

Catalog No. ABIN3044383

This Rabbit Polyclonal antibody specifically detects Presenilin 2 in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Presenilin 2 antibody (N-Term) (ABIN3044383)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Presenilin 2 Antibody

Binding Specificity: AA 39-51, N-Term

Purpose: Anti-Presenilin 2/PSEN2 Antibody Picoband®

Sequence: EDGENTAQWR SQE

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Presenilin 2/PSEN2 Antibody (ABIN3044383). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2, different from the related mouse and rat sequences by two amino acids.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). "A familial Alzheimer's disease locus on chromosome 1". 2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy".

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: PSEN2

Background:

Synonyms: Presenilin-2,PS-2,3.4.23.-,AD3LP,AD5,E5-1,STM-2,Presenilin-2 NTF subunit,Presenilin-2 CTF subunit,PSEN2,AD4, PS2, PSNL2, STM2,

Tissue Specificity: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. .

Background: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Sequence Similarities: Belongs to the peptidase A22A family.

Molecular Weight: 60 kDa

UniProt: P49810

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway