Bcl-2 antibody
Quick Overview for Bcl-2 antibody (ABIN306549)
Target
See all Bcl-2 (BCL2) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Isotype
- IgG
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Restrictions
- For Research Use only
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Alternative Name
- bcl-2
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Background
- Human hematopoetic malignancies are often characterized by gene rearrangements that deregulate gene expression. Antibodies to human bcl-2 (B cell leukemia/lymphoma 2) are directed against the gene isolated at the chromosomal breakpoint t(14,18) Bcl-2 which suppress programmed cell death (apoptosis) and appears to be modulated by association with bax, a cell death promoter. Synonyms: hbcl2, sheep anti human bcl 2, bcl-2.
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UniProt
- P10415
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Pathways
- MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Target
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