Adenovirus E1A antibody

Catalog No. ABIN306558

Product Details anti-Adenovirus E1A Antibody

Target: Adenovirus E1A (HAdV E1A) (Human Adenovirus E1A (HAdV E1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Adenovirus E1A antibody is un-conjugated

Application: Please inquire

Clone: M73

Isotype: IgG2a

Application Details

Restrictions: For Research Use only

Handling

Target Details for Adenovirus E1A

Target: Adenovirus E1A (HAdV E1A) (Human Adenovirus E1A (HAdV E1A))

Alternative Name: E1A (adenovirus early region 1) (HAdV E1A Products)

Target Type: Viral Protein

Background: The immunogen for the anti- 2 E1A was full length recombinant adenovirus 2 E1A protein. The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105. By immunoprecipitation, adenovirus 2E1A recognizes adenovirus 2 and 5 E1A proteins, 3 bands at 30-50kDa, as well as, E1A associated proteins. 293 cells can be used as positive control and HS27 cells as negative control. Synonyms: mouse anti E1A, Adenovirus Early Region 1, .

UniProt: P03254