CHEK1 antibody

Catalog No. ABIN306587

The Sheep Polyclonal anti-CHEK1 antibody has been validated for . It is suitable to detect CHEK1 in samples from Human, Mouse, Rat and Monkey.

Quick Overview for CHEK1 antibody (ABIN306587)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Sheep

Clonality: Polyclonal

Conjugate: This CHEK1 antibody is un-conjugated

Application: Please inquire

Product Details anti-CHEK1 Antibody

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Target Details for CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Alternative Name: chk 1 kinase

Background: The immunogen for anti-human chk-1 was a GST fusion protein corresponding to amino acid sequence 1-474 and having a molecular weight of 54 kD. One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2. Synonyms: sheep anti human chk 1 kinase, checkpoint kinase 1.

UniProt: O14757

Pathways: p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair