ErbB2/Her2 antibody (full length)

Catalog No. ABIN306627

The Sheep Polyclonal anti-ErbB2/Her2 antibody (ABIN306627) specifically detects ErbB2/Her2 in WB. The antibody is reactive with Human samples.

Quick Overview for ErbB2/Her2 antibody (full length) (ABIN306627)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ErbB2/Her2 Antibody

Binding Specificity: full length

Purpose: Sheep anti Human HER2/neu

Characteristics: c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25 % of primary breast and ovarian tumors were found to overexpress the protein.

Purification: Ammonium Sulfate Precipitation

Immunogen: Full-length recombinant c-erbB-2/HER2/neu protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: c-ErbB-2

Background: P185erbB2, MLN 19, CD340, c-ErbB-2

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development