Retinoblastoma Protein (Rb) antibody (AA 393-572)

Catalog No. ABIN306634

This Mouse Monoclonal antibody specifically detects Retinoblastoma Protein (Rb) in IP. It exhibits reactivity toward Human.

Quick Overview for Retinoblastoma Protein (Rb) antibody (AA 393-572) (ABIN306634)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma Protein (Rb) antibody is un-conjugated

Application: Immunoprecipitation (IP)

Clone: XZ104

Product Details anti-Retinoblastoma Protein (Rb) Antibody

Binding Specificity: AA 393-572

Purpose: Mouse anti Human Rb (Retinoblastoma)

Characteristics: The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.

Purification: Protein A/G Chromatography

Immunogen: A recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence

Isotype: IgG1

Application Details

Application Notes: Applications: Immunoprecipitation (not recommended for Western blotting or immunohistochemistry).

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for Retinoblastoma Protein (Rb)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Alternative Name: Rb (Retinoblastoma)

Background: Retinoblastoma-associated protein, pRb, pp110, p105-Rb

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases