EPH Receptor B1 antibody (C-Term)

Catalog No. ABIN306671

The Sheep Polyclonal anti-EPH Receptor B1 antibody is suitable to detect EPH Receptor B1 in samples from Human. It has been validated for IP.

Quick Overview for EPH Receptor B1 antibody (C-Term) (ABIN306671)

Target: EPH Receptor B1 (EPHB1)

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This EPH Receptor B1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-EPH Receptor B1 Antibody

Binding Specificity: AA 586-984, C-Term

Purpose: Sheep anti Human ELK rec tyr Kinase (Eph B1 Cy.)

Cross-Reactivity: Human

Characteristics: The immunogen used for the anti-human ephB1 (Elk receptor) Dcytoplasmic(CY) region was a GST fusion protein ephB1 (Elk receptor) CY corresponding to amino acid sequence 586-984 of the C terminal, cytoplasmic region and having a molecular weight of 116 kDa. EphB1, previously known as Elk (eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. EphB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. EphB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cell-cell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.

Purification: Ammonium Sulfate Precipitation

Immunogen: A GST fusion protein ephB1 (Elk receptor) - CY corresponding to amino acid sequence 586-984 of the C terminus region and having a molecular weight of 116 kDa

Isotype: IgG

Application Details

Application Notes: Applications: 1-10 μg/mL for Western Blotting and 10-20 μg/mL for immunoprecipitation.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Alternative Name: ELK rec tyr Kinase (Eph B1 Cy)

Background: Eph B1 (ELK receptor) cytoplasmic, Tyrosine-protein kinase receptor EPH-2, Ephrin type B receptor 1, HEK6

UniProt: P54762

Pathways: RTK Signaling