AKAP12 antibody

Catalog No. ABIN306674

The Sheep Polyclonal anti-AKAP12 antibody is suitable to detect AKAP12 in samples from Rat. It has been validated for IHC, WB and IP.

Quick Overview for AKAP12 antibody (ABIN306674)

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Reactivity: Rat

Host: Sheep

Clonality: Polyclonal

Conjugate: This AKAP12 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-AKAP12 Antibody

Purpose: Sheep anti Rat SSeCKS - myristylated (PKC) substrate

Characteristics: Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicated during the process of spermiogenesis and in the actin-based stellate morphology of mesangial cells

Purification: Ammonium Sulfate Precipitation

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blot (2-5 μg/mL), immunohistochemistry and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/ml

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for AKAP12

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Alternative Name: SSeCKS - myristylated (PKC) substrate

Background: SSeCKS, A-kinase anchor protein 12, AKAP12, src-suppressed C kinase substrate

UniProt: Q62766

Pathways: cAMP Metabolic Process