PTGER2 antibody

Catalog No. ABIN306864

Product Details anti-PTGER2 Antibody

Target: PTGER2 (Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTGER2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Cow, Human, Rat

Characteristics: Prostaglandin E2 Receptor Subtype EP2, Provided under license from Allergan, Inc. United States Patent No. 5,716,835,Prostaglandins (PG's) are produced by the metabolism of arachidonic acid. PGE-2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues are mediated through binding to the PGE-2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.

Purification: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human EP2 receptor protein and mouse myeloma cells.

Clone: 3E6

Isotype: IgG1

Application Details

Application Notes: This antibody can be used for Western blot analysis (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for PTGER2

Target: PTGER2 (Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2))

Alternative Name: Prostaglandin-E2 receptor EP2 (PTGER2 Products)

Synonyms: EP2 antibody, Ptgerep2 antibody, ptger2 antibody, ptger2l antibody, zgc:63974 antibody, MGC69060 antibody, PTGER2 antibody, Ptger-ep2 antibody, si:ch211-13n20.1 antibody, si:dkey-29m11.3 antibody, zgc:136608 antibody, prostaglandin E receptor 2 antibody, prostaglandin E receptor 2 (subtype EP2) antibody, prostaglandin E receptor 2a (subtype EP2) antibody, prostaglandin E receptor 2 S homeolog antibody, prostaglandin E receptor 2b (subtype EP2) antibody, PTGER2 antibody, Ptger2 antibody, ptger2a antibody, ptger2.S antibody, ptger2b antibody

UniProt: Q62928