Lamin A/C antibody (AA 398-490)

Catalog No. ABIN327793

This Mouse Monoclonal antibody specifically detects Lamin A/C in WB and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Lamin A/C antibody (AA 398-490) (ABIN327793)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 398-490

Specificity: Peptide from human lamin A/C corresponding to aa398-490. Recognizes Lamin A, Mr 74kD and Lamin C, Mr 65kD. Species cross-reactivity: Human, mouse, rat, chicken and canine.

Purification: Protein G purified

Immunogen: Peptide from human lamin A/C corresponding to aa398 to 490.

Type of Immunogen: Synthetic peptide

Isotype: IgG1

Application Details

Application Notes: Approved: ICC (0.5 - 2 μg/mL), WB

Usage: Suitable for use in Western Blot and Immunocytochemistry. Western Blot Analysis: 0.5-2 μg/mL of this lot detected Lamin A/C in 20 μg of RIPA lysates from A431 cells. Immunocytochemistry: This antibody has been reported by an independent laboratory to detect Lamin A/C in human endothelial cells.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 % storage buffer (20 mM sodium phosphate,  pH 7.5, 0.15 M sodium chloride, 1 mg/mL BSA, 0.09 % sodium azide), 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA / Lamin A/C

Background: Name/Gene ID: LMNA

Synonyms: LMNA, 70 kDa lamin, CDCD1, CMD1A, EMD2, FPLD, IDC, FPL, FPLD2, Lamin A/C, Lamin, LFP, LMNC, LMN1, LMNL1, HGPS, Prelamin-A/C, PRO1, Lamin A, Lamin A/C-like 1, LGMD1B, CDDC, CMT2B1, LDP1

This antibody detects: LMNA / Lamin A+C

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus