Ubinuclein 1 antibody (AA 1-190)

Catalog No. ABIN343714

This Mouse Monoclonal antibody specifically detects Ubinuclein 1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Ubinuclein 1 antibody (AA 1-190) (ABIN343714)

Target: Ubinuclein 1 (UBN1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ubinuclein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: UBN1-02

Product Details anti-Ubinuclein 1 Antibody

Binding Specificity: AA 1-190

Purpose: Anti-UBN1 Purified

Cross-Reactivity (Details): Human, Other species Not tested

Characteristics: The antibody UBN1-02 recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band.

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1.

Isotype: IgG1, kappa

Application Details

Application Notes: Western blotting: Recommended dilution: 1-5 μg/mL, positive control: HeLa cell line.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for Ubinuclein 1

Target: Ubinuclein 1 (UBN1)

Alternative Name: UBN1

Background: Ubinuclein 1,Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.,Ubinuclein 1, VT4

Gene ID: 29855

UniProt: Q6PIZ9