Ubinuclein 1 antibody (AA 1-345)

Catalog No. ABIN6972900

Product Details anti-Ubinuclein 1 Antibody

Target: Ubinuclein 1 (UBN1)

Binding Specificity: AA 1-345

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ubinuclein 1 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: UBN1 (Ubinuclein 1, also known as HIRA binding protein) is a ubiquitously expressed nuclear protein that acts as a novel regulator of senescence. UBN1 is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. It is expressed in a number of cancer cell lines and tumors and may be required for replication-independent chromatin assembly. UBN1 is part of a large multi-subunit protein complex that interacts with CEBPA and Epstein-Barr virus BLZF1. It co-localizes with HIRA, PML and SP100 in the PML bodies of senescent cells. When overexpressed, UBN1 accumulates in the nucleus of cells defective for cytokinesis. Ubn1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogen: This Ubinuclein antibody was raised against a recombinant protein corresponding to amino acids 1-345 of human Ubn1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for Ubinuclein 1

Target: Ubinuclein 1 (UBN1)

Alternative Name: Ubn1 (UBN1 Products)

Synonyms: ubinuclein-1 antibody, ubn1 antibody, VT antibody, VT4 antibody, 1110029L11Rik antibody, 2610108L02Rik antibody, AA673476 antibody, AW124741 antibody, ubinuclein 1 antibody, UBN1 antibody, ubn1 antibody, Ubn1 antibody

Molecular Weight: 145 kDa

NCBI Accession: NP_001072982