ALIX antibody

Catalog No. ABIN347079

This Rabbit Polyclonal antibody specifically detects ALIX in WB, ELISA, IHC and IF. It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for ALIX antibody (ABIN347079)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALIX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ALIX Antibody

Specificity: Reacts with human 91-93 kDa Alix protein

Purification: Antiserum

Immunogen: Recombinant Alix Protein

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1:200 - 1:1000) WB(1:200 - 1:1000)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

References for anti-ALIX antibody (ABIN347079)

Takahashi, Kojima, Zhang, Sasaki, Ito, Suzuki, Kawasaki, Wakatsuki, Takahara, Shibata, Maki: "Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2." in: International journal of molecular sciences, Vol. 16, Issue 2, pp. 3677-99, (2015) (PubMed).

Inuzuka, Inokawa, Chen, Kizu, Narita, Shibata, Maki: "ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by exosomal pathway and taken up by recipient cultured cells." in: Bioscience reports, (2013) (PubMed).

Pasqual, Rojek, Masin, Chatton, Kunz: "Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport." in: PLoS pathogens, Vol. 7, Issue 9, pp. e1002232, (2011) (PubMed).

Target Details for ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: ALIX

Background: ALIX belongs to the ESCORT machinery and is involved in multivesicular body (MVB) sorting. This function is used during HIV-1 budding. ALIX is also involved in apoptotic process.

Gene ID: 10015

UniProt: Q8WUM4

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation