ALIX antibody

Catalog No. ABIN347079

Product Details anti-ALIX Antibody

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALIX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Specificity: Reacts with human 91-93 kDa Alix protein

Purification: Antiserum

Immunogen: Recombinant Alix Protein

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1:200 - 1:1000) WB(1:200 - 1:1000)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

References for anti-ALIX antibody (ABIN347079)

Takahashi, Kojima, Zhang, Sasaki, Ito, Suzuki, Kawasaki, Wakatsuki, Takahara, Shibata, Maki: "Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2." in: International journal of molecular sciences, Vol. 16, Issue 2, pp. 3677-99, (2015) (PubMed).

Inuzuka, Inokawa, Chen, Kizu, Narita, Shibata, Maki: "ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by exosomal pathway and taken up by recipient cultured cells." in: Bioscience reports, (2013) (PubMed).

Pasqual, Rojek, Masin, Chatton, Kunz: "Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport." in: PLoS pathogens, Vol. 7, Issue 9, pp. e1002232, (2011) (PubMed).

Target Details for ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: ALIX (PDCD6IP Products)

Synonyms: DDBDRAFT_0167145 antibody, DDBDRAFT_0185177 antibody, DDB_0167145 antibody, DDB_0185177 antibody, AIP1 antibody, ALIX antibody, DRIP4 antibody, HP95 antibody, AI480591 antibody, AW544830 antibody, Aip1 antibody, Alix antibody, C76364 antibody, Eig2 antibody, mKIAA1375 antibody, CG12876 antibody, DAIP1 antibody, Dmel\\CG12876 antibody, GB11744 antibody, RGD1561176 antibody, zgc:63638 antibody, wu:fb70d03 antibody, wu:fy65h02 antibody, PDCD6IP antibody, aip1 antibody, alix antibody, hp95 antibody, drip4 antibody, ALG-2 interacting protein X antibody, programmed cell death 6 interacting protein antibody, programmed cell death 6-interacting protein antibody, Programmed cell death 6 interacting protein antibody, programmed cell death 6 interacting protein L homeolog antibody, alxA antibody, PDCD6IP antibody, Pdcd6ip antibody, ALiX antibody, LOC412662 antibody, pdcd6ip antibody, Bm1_48390 antibody, pdcd6ip.L antibody

Background: ALIX belongs to the ESCORT machinery and is involved in multivesicular body (MVB) sorting. This function is used during HIV-1 budding. ALIX is also involved in apoptotic process.

Gene ID: 10015

UniProt: Q8WUM4

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation