TRPV5 antibody (4th Cytoplasmic Loop)

Catalog No. ABIN351299

Product Details anti-TRPV5 Antibody

Target: TRPV5 (Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))

Binding Specificity: 4th Cytoplasmic Loop

Reactivity: Rabbit

Host: Sheep

Clonality: Polyclonal

Conjugate: This TRPV5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for TRPV5.

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of rabbit TRPV5 conjugated to an immunogenic carrier protein was used as the immunogen.

Isotype: IgG

Application Details

Application Notes: A concentration of 10-50 µg/ml is recommended.
The optimal dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TRPV5

Target: TRPV5 (Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))

Alternative Name: TRPV5 (TRPV5 Products)

Synonyms: CaT2 antibody, Ecac1 antibody, CAT2 antibody, ECAC1 antibody, OTRPC3 antibody, D630033B11 antibody, TRPV5 antibody, ECAC antibody, cat2 antibody, xcat2 antibody, transient receptor potential cation channel, subfamily V, member 5 antibody, transient receptor potential cation channel subfamily V member 5 antibody, calcium transporter 2 L homeolog antibody, Trpv5 antibody, TRPV5 antibody, LOC100011049 antibody, trpv5 antibody, cat2.L antibody

Background: This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
Function: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Subcellular location: Apical cell membrane, Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
Tissue specificity: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. Also known as: TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC, ECaC1, Calcium transport protein 2, CaT2, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5.