KDM3B antibody (N-Term)
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- Target See all KDM3B Antibodies
- KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))
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Binding Specificity
- N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KDM3B antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody will recognize JMJD1B (N-term).
- Purification
- Protein A Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Immunogen
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human JMJD1B.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product KDM3B Primary Antibody
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- Application Notes
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ELISA: 1/1,000. Western Blot: 1/250-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS containing 0.09 % (W/V) Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Target
- KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))
- Alternative Name
- JMJD1B / KDM3B (KDM3B Products)
- Synonyms
- KDM3B antibody, JMJD1B antibody, 5830462I21Rik antibody, JHDM2B antibody, Jmjd1b antibody, mKIAA1082 antibody, 5qNCA antibody, C5orf7 antibody, NET22 antibody, lysine demethylase 3B antibody, lysine (K)-specific demethylase 3B antibody, lysine-specific demethylase 3B antibody, KDM3B lysine (K)-specific demethylase 3B antibody, KDM3B antibody, LOC100540242 antibody, kdm3b antibody, Kdm3b antibody
- Background
- Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: 5qNCA, C5orf7, JHDM2B, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, KIAA1082, Lysine-specific demethylase 3B, Nuclear protein 5qNCA
- Gene ID
- 51780, 9606
- UniProt
- Q7LBC6
- Pathways
- Warburg Effect
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