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MLK4 antibody (N-Term)

KIAA1804 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN360429
  • Target See all MLK4 (KIAA1804) Antibodies
    MLK4 (KIAA1804) (Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804))
    Binding Specificity
    • 12
    • 9
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 31
    • 16
    • 1
    Human
    Host
    • 45
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 16
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLK4 antibody is un-conjugated
    Application
    • 32
    • 30
    • 27
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody recognizes MLK4 (N-term). Other species not tested.
    Purification
    Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MLK4.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product KIAA1804 Primary Antibody
  • Application Notes
    ELISA: 1/1,000 . Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % (W/V) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    MLK4 (KIAA1804) (Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804))
    Alternative Name
    MLK4 (KIAA1804 Products)
    Synonyms
    MLK4 antibody, RP5-862P8.2 antibody, dJ862P8.3 antibody, Mlk4 antibody, mKIAA1804 antibody, mitogen-activated protein kinase kinase kinase 21 antibody, MAP3K21 antibody, Map3k21 antibody
    Background
    Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the p38 and JNK signaling cascades. Systematic mutational analyses of tyrosine kinases reveal that a minimum of 30 % of colorectal cancer contain at least one mutation in the tyrosine kinases, sampling of colorect cancer cells suggest an important role of MLK4 in this process. Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.Synonyms: KIAA1804, MLK4, Mitogen-activated protein kinase kinase kinase
    Molecular Weight
    113957 Da
    Gene ID
    84451, 9606
    UniProt
    Q5TCX8
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