VEGFC antibody (Vascular Endothelial Growth Factor C)

Details for Product anti-VEGFC Antibody No. ABIN360868, Supplier: Log in to see
Antigen
  • VEGFC
  • vegf-c
  • xvegf-c
  • Flt4-L
  • VRP
  • AW228853
  • VEGF-C
  • vascular endothelial growth factor c
  • vascular endothelial growth factor C
  • vascular endothelial growth factor C S homeolog
  • vegfc
  • VEGFC
  • vegfc.S
  • Vegfc
Alternatives
anti-Human VEGFC antibody for Enzyme Immunoassay
Reactivity
Human, Rat (Rattus)
245
94
93
3
3
2
2
2
1
1
1
1
Host
Mouse
182
123
8
1
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This VEGFC antibody is un-conjugated
30
25
19
8
7
7
5
5
4
4
4
4
4
4
4
4
4
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
265
156
136
43
25
23
23
17
17
17
13
8
3
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen Recombinant Human VEGF-C protein (Cat.-No AR01001PU-N)
Clone 107F10
Isotype IgG2a
Specificity This antibody detects VEGF-C in Western Blots. No cross-reactivity is shown with VEGF-A.
Purification Protein G Affinity Chromatography
Plasmids, Primers & others Plasmids, Primers & others VEGFC products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name VEGF-C / Flt4-L (VEGFC Antibody Abstract)
Background VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.Synonyms: Flt4 ligand, VEGFC, VRP, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein
Gene ID 7424
NCBI Accession NP_005420
UniProt P49767
Pathways RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore in sterile water to a concentration of 0.1-1.0 mg/mL. Centrifuge vial prior to opening.
Buffer PBS without preservatives or stabilizers
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store at -20 °C. This product should be stored undiluted.
Background publications Olofsson, Jeltsch, Eriksson, Alitalo: "Current biology of VEGF-B and VEGF-C." in: Current opinion in biotechnology, Vol. 10, Issue 6, pp. 528-35, 2000 (PubMed).

Joukov, Pajusola, Kaipainen, Chilov, Lahtinen, Kukk, Saksela, Kalkkinen, Alitalo: "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases." in: The EMBO journal, Vol. 15, Issue 2, pp. 290-98, 1996 (PubMed).

Did you look for something else?