mGluR2/3 antibody (C-Term)

Catalog No. ABIN361454

The Rabbit Polyclonal anti-mGluR2/3 antibody has been validated for WB. It is suitable to detect mGluR2/3 in samples from Rat.

Quick Overview for mGluR2/3 antibody (C-Term) (ABIN361454)

Target: mGluR2/3 (GRIA2/3) (Glutamate Receptor, Ionotropic, AMPA 2/3 (GRIA2/3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This mGluR2/3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-mGluR2/3 Antibody

Binding Specificity: C-Term

Specificity: Specific for the ~100k GluR2/3 protein.

Cross-Reactivity: Rat (Rattus)

Predicted Reactivity: chicken, human, mouse, zebra fish

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for mGluR2/3

Target: mGluR2/3 (GRIA2/3) (Glutamate Receptor, Ionotropic, AMPA 2/3 (GRIA2/3))

Alternative Name: GRIA2/3

Background: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by (-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990,Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003,Seidenman et al., 2003,Chung et al., 2003,Yan et al., 2002). Anti-GluR2/3 Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein.

Molecular Weight: '100 kDa

Gene ID: 29627

UniProt: P19491