mGluR2/3 antibody (C-Term)

Catalog No. ABIN6658279

Product Details anti-mGluR2/3 Antibody

Target: mGluR2/3 (GRIA2/3) (Glutamate Receptor, Ionotropic, AMPA 2/3 (GRIA2/3))

Binding Specificity: C-Term

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This mGluR2/3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Anti-GluR2/3 Antibody is directed against rat GluR2/3 protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: chicken, human, mouse and zebra fish.

Immunogen:

Immunogen: Anti-GluR2/3 Antibody was produced by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region.

Immunogen Type: Peptide

Isotype: IgG

Application Details

Application Notes:

Application Note: Anti-GluR2/3 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 100 kDa in size corresponding to GluR2/3 protein in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Target Details for mGluR2/3

Target: mGluR2/3 (GRIA2/3) (Glutamate Receptor, Ionotropic, AMPA 2/3 (GRIA2/3))

Alternative Name: GluR2/3 (GRIA2/3 Products)

Synonyms: glutamate ionotropic receptor AMPA type subunit 2 antibody, GRIA2 antibody

Background:

Synonyms: Glutamate receptor 2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2

Background: GluR2/3 Antibody detects GluR2/3 protein. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory. Therefore, GluR2/3 is ideal for investigators involved in synaptic plasticity study and more in general in Neuroscience.

Gene Name: GRIA2/3

Gene ID: 29627

UniProt: P19491