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VAV1 antibody (pTyr174)
VAV1
Reactivity: Human, Rat, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-VAV1 Antibody
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Target
See all VAV1 Antibodies
VAV1
(Vav 1 Oncogene (VAV1))
Binding Specificity
All epitopes for VAV1 antibodies
pTyr174
Reactivity
All reactivities for VAV1 antibodies
Human, Rat, Mouse
Host
All hosts for VAV1 antibodies
Rabbit
Clonality
All clonalities for VAV1 antibodies
Polyclonal
Conjugate
All conjugates for VAV1 antibodies
This VAV1 antibody is un-conjugated
Application
All applications for VAV1 antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous level of Vav only when phosphorylated at tyrosine 174.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pTyr174 (E-I-Y (p) -E-D) derived from Human Vav. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype
IgG
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Application Details
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Application Notes
Western blotting: 1:500-1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
References for anti-VAV1 antibody (ABIN362132)
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Sekine, Ikeda, Tsuji, Yamamoto, Muromoto, Nanbo, Oritani, Yoshimura, Matsuda : "Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 183 , Issue 12 , pp. 7966-74 , (2009 ) (PubMed ).
Target Details for VAV1
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Target
VAV1
(Vav 1 Oncogene (VAV1))
Alternative Name
Vav (VAV1 Products )
Synonyms
VAV antibody, Vav antibody, vav-T antibody, vav guanine nucleotide exchange factor 1 antibody, vav 1 oncogene antibody, vav guanine nucleotide exchange factor 1 L homeolog antibody, VAV1 antibody, Vav1 antibody, vav1.L antibody
Background
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation
Molecular Weight
95 kDa
NCBI Accession
NP_005419
UniProt
P15498
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , CXCR4-mediated Signaling Events , BCR Signaling
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