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TNFRSF19 antibody (AA 29-44)

TNFRSF19 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372452
  • Target See all TNFRSF19 Antibodies
    TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19))
    Binding Specificity
    • 15
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 29-44
    Reactivity
    • 38
    • 14
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    Human, Mouse
    Host
    • 37
    • 5
    Rabbit
    Clonality
    • 37
    • 5
    Polyclonal
    Conjugate
    • 18
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNFRSF19 antibody is un-conjugated
    Application
    • 37
    • 14
    • 13
    • 13
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody recognizes TNFRSF19.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Protein G Chromatography.
    Immunogen
    A mixture of synthetic peptides corresponding to amino acids 29-44, 204-219, and 409-421 of Human TROY.
    Isotype
    IgG
    Top Product
    Discover our top product TNFRSF19 Primary Antibody
  • Application Notes
    Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 0.5-2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    TNFRSF19 (Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19))
    Alternative Name
    TNFRSF19 / TRADE (TNFRSF19 Products)
    Synonyms
    TNFRSF19 antibody, DKFZp468A0320 antibody, TAJ antibody, TAJ-alpha antibody, TRADE antibody, TROY antibody, AL023044 antibody, AW123854 antibody, TAJ-ALPHA antibody, Troy antibody, RGD1564996 antibody, TNF receptor superfamily member 19 antibody, tumor necrosis factor receptor superfamily, member 19 antibody, TNFRSF19 antibody, Tnfrsf19 antibody
    Background
    Analysis of EST clones and use of a signal sequence trap screening of the murine brain have lead to identification of a new member of the tumor necrosis factor receptor superfamily designated as TAJ and TROY, respectively. TAJ/TROY is a membrane protein of 423 amino acids with characteristic cysteine-rich motifs in the extracellular domain and a tumor necrosis factor receptor-associated factor (TRAF) 2 binding sequence in the cytoplasmic domain. Human TROY has 78 % identity at the amino acid level with mouse TROY. The extracellular domain of TROY has significant homology with that of EDAR (another newly identified receptor belonging to TNF receptor family) that specifies hair follicle fate. The cytoplasmic domain of TAJ is different than other TNF receptor family members. Although its cytoplasmic domain does not contain death domain, TAJ/TROY induced cell death is probably mediated through a caspase-independent pathway. TAJ-induced JNK activation was not blocked by dominant-negative inhibitors of TRAF2, TRAF5, or ASK1, which have been previously implicated in JNK activation via TNFR1 and CD40. However, coimmunoprecipitation assays revealed that TAJ is capable of binding a number of different TRAF family members, and it is possible that TAJ-induced JNKactivation is mediated by an as yet untested TRAF homolog, such as TRAF6. TROY mRNA is highly expressed in brain, prostate and embryo and moderately expressed in the heart, lung, liver.Synonyms: TAJ, TROY, Toxicity and JNK inducer, Tumor necrosis factor receptor superfamily member 19
    Gene ID
    55504
    NCBI Accession
    NP_001191387
    UniProt
    Q9NS68
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